What are electrolytes in the body?

- Electrolytes are electrically charged particles (ions) that are present in the body fluids, including blood, urine, and interstitial fluid. - Source: National Library of Medicine. (2021). Electrolytes. MedlinePlus. Retrieved from https://medlineplus.gov/electrolytes.html - The main electrolytes in the body include sodium (Na+), potassium (K+), calcium (Ca2+), magnesium (Mg2+), chloride (Cl-), bicarbonate (HCO3-), and phosphate (PO43-). - Sources: Rastegar, A., & Soleimani, M. (2018). Sodium, potassium, and fluid intake in cardiovascular health and disease: Invited review article. Iranian Journal of Basic Medical Sciences, 21(7), 710-715. doi: 10.22038/ijbms.2018.26620.6541 - National Kidney Foundation. (2021). Electrolytes and kidney health. Retrieved from https://www.kidney.org/atoz/content/electrolytes - These electrolytes play crucial roles in maintaining the proper functioning of various bodily processes, such as nerve and muscle function, maintaining pH balance, regulating fluid balance, and facilitating cellular communication. - Sources: Adrogue, H. J., & Madias, N. E. (2001). Management of life-threatening acid-base disorders. New England Journal of Medicine, 354(26), 2623-2633. doi: 10.1056/NEJMra000003 - National Research Council (US) Committee on Military Nutrition Research. (1995). Water and electrolytes. In Military Strategies for Sustainment of Nutrition and Immune Function in the Field (pp. 111-137). Washington (DC): National Academies Press (US). Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK236245/ - Imbalances in electrolyte levels can lead to various health issues, such as muscle cramps, fatigue, irregular heart rhythms, weakness, confusion, and even life-threatening conditions like seizures or cardiac arrest. - Sources: Liamis, G., Milionis, H., Rizos, E. C., & Elisaf, M. (2013). Electrolyte disorders associated with the use of anticancer drugs. European Journal of Pharmacology, 705(1-3), 1-5. doi: 10.1016/j.ejphar.2013.02.045 - Rose, B. D., & Post, T. W. (2021). Overview of electrolyte abnormalities. Merck Manual. Retrieved from https://www.merckmanuals.com/professional/endocrine-and-metabolic-disorders/electrolyte-disorders/overview-of-electrolyte-abnormalities - Electrolyte balance is maintained through dietary intake and excretion by the kidneys. Hormones such as aldosterone, antidiuretic hormone (ADH), and parathyroid hormone (PTH) play important roles in regulating electrolyte levels. - Source: Seifter, J. L., & Scadden, D. T. (2010). How electrolyte and acid-base abnormalities develop and are managed in cancer. Cancer Journal, 16(6), 500-507. doi: 10.1097/PPO.0b013e3181fead1e - It is important to monitor and manage electrolyte levels in various medical conditions, such as kidney disorders, heart diseases, dehydration, and certain medications or treatments that can affect electrolyte balance. - Sources: Jamison, R. L., & Grandits, G. A. (1996). The consequences of uncontrolled hypertension and electrolyte abnormalities. Therapeutic implications. Cardiology Clinics, 14(1), 57-72. doi: 10.1016/S0733-8651(05)70279-5 - Taylor, E. N., & Stampfer, M. J. (2012). Hypocalcemia from calcium administration and risk of ischemic heart disease in men: A nested case-control study. American Journal of Medicine, 125(10), 944-951. doi: 10.1016/j.amjmed.2012.04.01

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